Mladen Koravović, M. Pharm.

Mladen Koravovic completed primary and secondary education with an average grade of 5.00. He enrolled in Integrated Academic Studies, Pharmacy program, at the University of Belgrade – Faculty of Pharmacy. Throughout his studies, he was awarded the Annual Award, which is granted to the best students of integrated academic studies for the academic years 2012/2013 (average grade 9.91), 2013/2014 (average grade 9.95), 2014/2015 (average grade 9.97), and 2015/2016 (average grade 9.79). He graduated from the faculty with an average grade of 9.73 and 308 ECTS credits, defending his final thesis titled "Quantitative Structure-Activity Relationships of EZH2 (Enhancer of Zeste Homolog 2) Inhibitors" with a grade of 10 (ten), under the mentorship of Prof. Dr. Slavica Erić (Department of Pharmaceutical Chemistry). Additionally, he earned 8 additional ECTS credits by completing an elective course on Contemporary Pharmaceutical Forms during the fifth year of study (5 ECTS) with a grade of 10 (ten) and by publishing papers (3 ECTS). After completing his internship for pharmacists, he passed the professional exam and obtained a license.

He enrolled in Doctoral Academic Studies, Pharmaceutical Chemistry module, at the University of Belgrade – Faculty of Pharmacy. He was appointed as Junior Research Assistant on January 31, 2019, at the same faculty. Since then, he has been employed at the Department of Organic Chemistry as a Junior Research Assistant within the Project of the Ministry of Education, Science and Technological Development of the Republic of Serbia entitled "Computational design, synthesis and biological evaluation of novel heterocyclic compounds as selective anticancer agents". Currently, he holds the position of Research Assistant at the same department to conduct scientific research under the Agreement with the Ministry of Science, Technological Development and Innovation of the Republic of Serbia regarding the implementation and financing of scientific research. From October 2, 2022, to November 24, 2022, he was on a study visit at St. Jude Children's Research Hospital (Memphis, USA) under the Agreement on the funding of the implementation of a scientific research Project entitled "Design and synthesis of Hsp90 PROTAC degraders as potential anticancer agents" (acronym: DeSyHPRO, registration number: 6463913, project leader: Prof. Dr. Vladimir Savić), within the Serbian Science and Diaspora Collaboration Program: Knowledge Exchange Vouchers.

At the session held on November 30, 2021, the Council of Scientific Fields of Medical Sciences adopted Decision (number: 61206-4569/2-21) to approve the Decision of the Teaching and Scientific Council of the University of Belgrade - Faculty of Pharmacy to accept the topic of Mladen Koravovic's doctoral dissertation entitled "Design, Synthesis, and Biological Characterization of Small Organic Molecules Inducing Degradation of HSP90 and BET Proteins" and appoint Prof. Dr. Vladimir Savić (Department of Organic Chemistry) and Prof. Dr. Bojan Marković (Department of Pharmaceutical Chemistry) as mentors.

Mladen Koravovic's research is focused on the design, synthesis, and biological characterization of molecules (PROTAC molecules, HyT molecules, etc.) that induce the degradation of therapeutically relevant proteins (HSP90, BET proteins, etc.).

• Koravovic, M.; Mayasundari, A.; Tasic, G.; Keramatnia, F.; Stachowski, T. R.; Cui, H.; Chai, S. C.; Jonchere, B.; Yang, L.; Li, Y.; Fu, X.; Hiltenbrand, R.; Paul, L.; Mishra, V.; Klco, J. M.; Roussel, M. F.; Pomerantz, W. CK.; Fischer, M.; Rankovic, Z.; Savic, V. From PROTAC to Inhibitor: Structure-Guided Discovery of Potent and Orally Bioavailable BET Inhibitors. European Journal of Medicinal Chemistry2023, 251, 115246. https://doi.org/10.1016/j.ejmech.2023.115246.
  
• Koravović, M.; Marković, B.; Kovačević, M.; Rmandić, M.; Tasić, G. Protein Degradation Induced by PROTAC Molecules as an Emerging Drug Discovery Strategy: Survey. Journal of the Serbian Chemical Society2022, 87 (7–8), 785–811. https://doi.org/10.2298/JSC211209027K.
• Koravović, M.; Tasić, G.; Rmandić, M.; Marković, B. Photocontrollable PROTAC Molecules: Structure and Mechanism of Action. Arhiv za farmaciju2021, 71 (3), 161–176. https://doi.org/10.5937/arhfarm71-30785.
• Koravović, M.; Tasić, G.; Mayasundari, A.; Keramatnia, F.; Fischer, M.; Ranković, Z.; Savić, V. Sinteza i biološko profilisanje (+)-JQ1 amida kao BET inhibitora. 57. Savetovanje Srpskog hemijskog društva2021, 86–86.